Boris Johnson will be questioned by senior MPs later amid continued calls for his top adviser to resign.
It marks the first time he has appeared before the Commons Liaison Committee – the only committee that gets to question the PM – since taking office.
Committee members are expected to ask Mr Johnson about the government’s handling of the coronavirus pandemic.
He is also likely to be asked about his aide Dominic Cummings’ controversial lockdown trip to County Durham.
More than 35 Tory MPs have called for Mr Cummings to resign or be fired after his 260-mile journey came to light.
Mr Cummings’ decision in March to drive from his London home to his parents’ farm in County Durham with his wife – who had coronavirus symptoms – and his son has dominated the headlines since the story broke on Friday night.
The PM’s chief adviser gave a news conference on Monday, explaining that he decided to make the trip because he felt it would be better to self-isolate in a place where he had options for childcare if required.
He has received the continued support of the prime minister, who said that his aide had acted legally and with integrity.
But cross-party critics have called for Mr Cummings to leave No 10, while junior minister Douglas Ross resigned in protest.
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Mr Cummings has defended his trip to County Durham during lockdown
Conservative MP Craig Whittaker told BBC Two’s Newsnight that Mr Cummings’ position was “untenable”, adding: “I respect he is taking a decision but what I can’t get my head around is why he can’t take responsibility for that decision.”
The Liaison Committee – a panel of MPs who chair various select committees – is the only Commons committee that can question the prime minister. The two-hour video conference will take place at 16:30 BST.
The committee’s new chairman, Sir Bernard Jenkin, announced the session last week – before Mr Cummings’ controversial trip came to light.
Sir Bernard said the coronavirus crisis had “led to a centralisation of power”, making the prime minister “more personally accountable than usual”.
Mr Johnson had previously been accused of dodging scrutiny after pulling out of an appearance in front of the committee in October last year.
At the time, the prime minister justified the decision by saying he had to “focus on delivering Brexit”.
Sir Bernard was appointed to his new role a week ago – despite a cross-party attempt to block it after a dispute over the procedure.
He had been nominated to chair the committee by the government, even though he no longer chairs a committee of his own.
Sir Bernard, who previously chaired the Public Administration Committee, was a leading member, alongside Mr Johnson, of the 2016 campaign to get Britain out of the EU.
The Liaison Committee, which has held scrutiny sessions with prime ministers since 2002, is made up of 37 Tory, Labour and SNP MPs who head up other committees in Parliament.
Sir Bernard will be joined in his questioning of the PM by Labour MPs Hilary Benn and Sarah Champion, Tory MPs Karen Bradley and Greg Clark, and the SNP’s Pete Wishart.
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Conservative MP Tobias Ellwood – who chairs the defence select committee – appeared unhappy on Twitter that he was not on the list, and was retweeted by fellow Tory Tom Tugendhat, who chairs the foreign affairs committee.
But a statement from Sir Bernard said the whole Liaison Committee had “unanimously agreed” the members of the working group who would be joining him for the session.